게재지

한국식품과학회지  (SCOPUS)

발행일

2022, vol.54, no.6, pp. 606-613 (8 pages)

Abstract

This study aimed to evaluate the anti-inflammatory and anti-gout effects of asparagus root water extract (ARW).

ARW was not cytotoxic up to 500 μ g/mL and effectively inhibited nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages. It was confirmed that the mRNA and protein expression levels of COX-2 and iNOS decreased at an ARW concentration of 500 μ g/mL. We also explored the anti-gout effects using a monosodium urate-induced mouse model. Decreased concentrations of uric acid, creatinine, and blood urea nitrogen were observed at an ARW concentration of 400 μ g/mL. The mRNA and protein expression of URAT1 and GLUT9 in the mouse kidney decreased to the level of the positive control (allopurinol 50 μ g/mL) at an ARW concentration of 400 μ g/mL. We analyzed the caffeic acid and rutin contents in the ARW using HLPC; the results obtained were 1.25 and 0.08 mg/g, respectively. We suggest that ARW can be used as a functional materials agent, for its anti-inflammatory and anti-gout properties.